200. Advanced Experimental Statistics. (4) (Formerly numbered M200.) Lecture, four hours; laboratory, one hour. Introduction to statistics with focus on computer simulation instead of formulas. Bootstrap and Monte Carlo methods used to analyze physiological data. S/U or letter grading.
M202. Cellular Neurophysiology. (4) (Same as Neurobiology M200F and Neuroscience M202.) Lecture, three hours; discussion, two hours. Requisites: courses 111A (or M180A or Physics 5C), 166. Advanced course in cellular physiology of neurons. Action and membrane potentials, channels and channel blockers, gates, ion pumps and neuronal homeostasis, synaptic receptors, drug-receptor interactions, transmitter release, modulation by second messengers, and sensory transduction. Letter grading.
CM203. Human Physiological Systems for Bioengineering II. (4) (Same as Bioengineering CM203.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Molecular-level understanding of human anatomy and physiology in selected organ systems (digestive, skin, musculoskeletal, endocrine, immune, urinary, reproductive). System-specific modeling/simulations (immune regulation, wound healing, muscle mechanics and energetics, acid-base balance, excretion). Functional basis of biomedical instrumentation (dialysis, artificial skin, pathogen detectors, ultrasound, birth-control drug delivery). Concurrently scheduled with course CM103. Letter grading.
CM204. Human Physiological Systems for Bioengineering I. (4) (Same as Bioengineering CM202.) Lecture, three hours; laboratory, two hours. Preparation: human molecular biology, biochemistry, and cell biology. Not open for credit to Physiological Science majors. Broad overview of basic biological activities and organization of human body in system (organ/tissue) to system basis, with particular emphasis on molecular basis. Modeling/simulation of functional aspect of biological system included. Actual demonstration of biomedical instruments, as well as visits to biomedical facilities. Concurrently scheduled with course CM102. Letter grading.
M210. Molecular and Cellular Mechanisms of Neural Integration. (5) (Same as Neuroscience M230 and Physiology M210.) Lecture, four hours; discussion, one hour. Requisite: Neuroscience M202. Introduction to mechanisms of synaptic processing. Selected problems of current interest, including regulation and modulation of transmitter release, molecular biology and physiology of receptors, cellular basis of integration in sensory perception and learning, neural nets and oscillators, and molecular events in development and sexual differentiation. Letter grading.
211. Exercise Cardiovascular Physiology. (4) Attention to cardiovascular adaptations to acute exercise as well as adaptations associated with regular exercise training.
215. Molecular and Cellular Foundations of Physiology. (5) (Formerly numbered M215.) Lecture, three hours; discussion, two hours. Application of molecular and cellular approaches to systems level questions. Basic foundation for study of major physiological systems, with emphasis on levels of organization from molecular to macroscopic. Letter grading.
CM223. Neurobiology of Sleep. (4) (Formerly numbered C223.) (Same as Neuroscience CM223.) Lecture, three hours; discussion, one hour. Detailed look into science of sleep. Cellular and molecular mechanisms of falling asleep, many discrete brain structures involved in control of sleep wakefulness, and homeostatic regulation of sleep. How our sleep needs shaped by our evolutionary history, age, and gender. Latest insights into question of function of sleep, critical role sleep plays in memory formation and, close association between sleep and metabolism. Sleep disorders are considered as they provide insights into mechanisms underlying sleep. For background on science of sleep and circadian rhythms, completion of course C126 is highly recommended. Concurrently scheduled with course CM123. Letter grading.
C226. Biological Clocks. (4) Lecture, three hours; discussion, one hour. Requisites: courses 111A and 111B, or M180A and M180B. Most organisms, including humans, exhibit daily rhythms in physiology and behavior. In many cases these rhythms are generated from within organisms and are called circadian rhythms. Biological basis of these daily rhythms or circadian oscillations. Exploration of molecular, cellular, and system-level organization of these timing systems. Temporal role of these variations in maintaining homeostatic mechanisms of body and impact on nervous system. Concurrently scheduled with course C126. Letter grading.
CM227. Neuroendocrinology of Reproduction. (4) (Same as Neurobiology M227.) Lecture, three hours. Enforced requisite: course 111B. Understanding of reproductive neuroendocrinology throughout mammalian lifespan, with emphasis as appropriate on human condition. Discussion of general concepts of endocrine feedback and feed-forward loops, sexual differentiation, and structure and function for components of hypothalamo-pituitary gonadal axis. Exploration of sex differences in physiology and disease. Concurrently scheduled with course C127. Letter grading.
C230. Sex Differences in Physiology and Disease. (4) Lecture, three hours. Requisites: course 111B, Life Sciences 7A, 7B, 7C. Investigation of biological origins of sex differences in physiology (mostly vertebrate), and susceptibility to disease, including history of development of concepts to define sex, and interface between biological factors and effects of gendered environments. Topics include evolution of sex chromosomes, molecular and environmental determination of gonadal type, dosage compensation, gonadal steroid hormone effects on tissues, physiology of reproduction as it applies to sex differences, interaction of genetic and environmental factors in differentiation of two sexes, defining sex and gender, gendered environments and their influence on physiology, and politics of financial support for research of sex and gender differences in disease. Concurrently scheduled with course C130. Letter grading.
235. Advanced Dynamical Systems Modeling of Physiological Processes. (5) Lecture, four hours; laboratory, two hours. Examination of art of making and evaluating dynamical models of physiological systems and of dynamical principles inherent in physiological systems. Letter grading.
241. Neural Plasticity and Repair. (4) Lecture, four hours. Preparation: basic neuroscience background. Progress in basic and clinical neuroscience provides new insight to understand mechanisms of cell repair and strategies to promote neural healing. Focus on physiological, molecular, and anatomical basis governing repair processes in brain and spinal cord and their clinical implications. Letter grading.
C244. Neural Control of Physiological Systems. (4) Lecture, four hours. Requisite: course 111B or M180B. Role of central nervous system in control of respiration, circulation, sexual function, and bladder control. Material for each section to be developed by combination of lecture and open discussion. Concurrently scheduled with course C144. Letter grading.
245. Neural Mechanisms Controlling Movement. (5) Lecture, four hours. Requisite: course 111A or M180A or Neuroscience M101A. Examination of central nervous system organization required for production of complex movements such as locomotion, mastication, and swallowing. Letter grading.
250A. Muscle Dynamics. (4) Lecture, four hours. Integrated study of electrical and dynamic parameters of muscle-action, including topics in length-tension and force-velocity interrelationships; critical analysis of electromyographic and digital computer techniques. Letter grading.
C250B. Musculoskeletal Mechanics. (5) Lecture, three hours. Requisites: course 107, Physics 6A. Introduction to biomechanical analysis of human musculoskeletal system. Examination of cinematographic, force platform, and digital computer techniques to characterize and evaluate kinematic and kinetic components of movement. Topics include biostatics, biodynamics, and modeling. Concurrently scheduled with course C150. Letter grading.
C252. Musculoskeletal Anatomy, Physiology, and Biomechanics. (5) Lecture, three hours. Requisite: course 111A. Anatomical, physiological, and mechanical characteristics of cartilaginous, fibrous, and bony tissues examined in normal and abnormal stress situations. Connective tissue growth processes, normal physiology, and repair mechanisms analyzed in conjunction with musculoskeletal injuries and effects of exercise. Concurrently scheduled with course C152.
M255. Seminar: Neural and Behavioral Endocrinology. (2) (Same as Neurobiology M255 and Psychology M294.) Seminar, one hour; discussion, one hour. Topics include hormonal biochemistry and pharmacology. Hypothalamic/hypophyseal interactions, both hormonal and neural. Structure and function of hypothalamus. Hormonal control of reproductive and other behaviors. Sexual differentiation of brain and behavior. Stress: hormonal, behavioral, and neural aspects. Aging of reproductive behaviors and function. Letter grading.
260. Neuromuscular Factors in Movement Regulation. (4) Lecture, four hours. Requisite: course 138. Interaction of neural and muscular factors in regulation of muscle fiber properties and importance of these properties in neural strategies of movement regulation. S/U or letter grading.
263. Neuronal Mechanisms Controlling Rhythmical Movements. (4) Lecture, four hours. Requisite: course M145. Advanced topics on brainstem mechanisms responsible for controlling cyclic and stereotypic movements such as mastication and locomotion. Emphasis on cellular neurophysiology and interaction between neuronal networks. Introduction to primary literature and techniques used in these areas. Students expected to critically evaluate data and conclusions drawn. S/U or letter grading.
270A-270B. Modern Concepts in Physiology. (4-4) Lecture, two hours; discussion, two hours. Study and evaluation of primary research literature. Study of foundations of modern techniques in physiology research, analysis of research design. Letter grading. 270A. Highly recommended requisite or corequisite: course 111A. Foundation for experimental study of principles of muscular and neural physiology and cellular and systems neuroscience, including factors controlling membrane excitability, neuronal circuits, sensorimotor regulation, special senses, cortical functions, and neural plasticity. 270B. Highly recommended requisite or corequisite: course 111B. Foundation for experimental study of principles of systems physiology, including endocrinology, transport physiology, and neural, cardiovascular, and pulmonary physiology.
M272. Neuroimaging and Brain Mapping. (4) (Same as Neuroscience CM272 and Psychology M213.) Lecture, three hours. Requisites: course M202, Neuroscience M201. Theory, methods, applications, assumptions, and limitations of neuroimaging. Techniques, biological questions, and results. Brain structure, brain function, and their relationship discussed with regard to imaging. Letter grading.
289A-289B. Introduction to Integrative Biology and Physiology. (2-3) Seminar, one hour. Limited to departmental graduate students. Letter grading. 289A. (Formerly numbered 289.) Introduction to departmental faculty research program. Students have three laboratory rotations at end of which they must select one research mentor. 289B. Requisite: course 289A. Introduction to departmental faculty research program.
M290. Seminar: Comparative Physiology. (2) (Same as Ecology and Evolutionary Biology M290.) Seminar, two and one half hours. Discussion of specific topics in comparative physiology of animals. Topics vary from year to year, with emphasis on systems physiology, neuroethology, or behavioral physiology. S/U or letter grading.
291A-291B-291C. Seminars: Cardiovascular Function and Adaptation. (2 to 4 each) Seminar, two to four hours. Selected topics on cardiovascular function and adaptation. Students required to present two-hour seminar. Letter grading.
292. Evolution and Development of Auditory System. (2 or 4) Seminar, two hours. Discussion of specific topics related to evolution, embryology, morphogenesis, cytodifferentiation, and onset of function of auditory system, with special attention to centrifugal pathways. Emphasis on primary literature sources as well as current methodological approaches. Two-hour seminar presentation required for 2 units; seminar paper and two-hour seminar presentation required for 4 units. S/U or letter grading.
293A-293B-293C. Seminars: Musculoskeletal Function and Adaptation. (2 to 4 each) Seminar, one hour. Requisites: courses 138, 260. Selected topics on muscular determinants of movement, metabolic aspects of exercise, and mechanics of connective tissue. Students required to present two-hour seminar. S/U or letter grading.
294. Recent Advances in Neurophysiology. (1) Seminar, one hour. Requisite: Life Sciences 2 or undergraduate degree in science. Critical examination and discussion of recent data and publications that focus on synaptic function. Student presentations, readings, and participation in discussions required. S/U grading.
295A-295B-295C. Seminars: Cellular Neuroscience. (2 to 4 each) Seminar, two to four hours. Requisite: course M202. Selected topics in sensory transduction, cellular integration, synaptic processing, central nervous system function, and learning. Students required to present two-hour seminar. S/U or letter grading.
296. Research Seminar: Physiological Science. (2) Review of literature, discussion of original research, and analysis of current topics in physiological science. May not be applied toward MS or PhD course requirements. May be repeated for credit. S/U grading.
297. Seminar: Muscle Cell Biology. (2 to 4) Seminar, two hours. Selected topics in muscle cell biology. Students required to present two-hour seminar. May be repeated for credit.
298. Seminar: Nervous System Development. (1 to 2) Seminar, two hours. Selected topics in developmental neurobiology, such as neuronal migration, axonal guidance, gene expression, and synaptogenesis. Weekly primary literature student presentations. One-hour seminar presentation on assigned weekly reading required of all students; students enrolled for 2 units must also complete written analysis of additional primary literature papers. May be repeated for credit. S/U or letter grading.
375. Teaching Apprentice Practicum. (1 to 4) Seminar, to be arranged. Preparation: apprentice personnel employment as teaching assistant, associate, or fellow. Teaching apprenticeship under active guidance and supervision of regular faculty member responsible for curriculum and instruction at UCLA. May be repeated for credit. S/U grading.
495. In-Service Practicum for Teaching Assistants in Physiological Science. (2) Seminar, to be arranged. Required of all teaching assistants. Supervised practicum in teaching laboratory courses in physiological science; material preparation and use of teaching aids. May not be applied toward degree requirements. S/U grading.
501. Cooperative Program. (2 to 8) Preparation: consent of UCLA graduate adviser and graduate dean, and host campus instructor, department chair, and graduate dean. Used to record enrollment of UCLA students in courses taken under cooperative arrangements with USC. S/U grading.
596. Individual Studies for Graduate Students. (2 to 8) Tutorial, to be arranged. To enroll for letter grade, petition signed by faculty sponsor, graduate adviser, and graduate affairs committee chair must be submitted prior to end of second week of class. Eight units may be applied toward degree requirements for MS or PhD degree, provided that students enroll in two different 4-unit 596 courses in different laboratories under supervision of different mentors. Term paper required for letter grading. S/U or letter grading.
597. Preparation for MS Comprehensive Examination or PhD Qualifying Examinations. (2 to 16) Tutorial, to be arranged with faculty member serving as student’s comprehensive examination chair or PhD committee chair. May not be applied toward MS or PhD course requirements. May be repeated as necessary. S/U grading.
598. Research for and Preparation of MS Thesis. (2 to 16) Tutorial, to be arranged with faculty member serving as student’s thesis committee chair. May not be applied toward MS course requirements. May be repeated as necessary. S/U grading.
599. Research for and/or Preparation of PhD Dissertation. (2 to 16) Tutorial, to be arranged. May not be applied toward PhD course requirements. May be repeated as necessary. S/U grading.