Submitted

DYT1 dystonia patient-derived fibroblasts have increased deformability and susceptibility to damage by mechanical forces. Gill NK, Ly C, Kim P, Fong LG, Young SG, Saunders CA, Luxton GWG, Rowat AC.

A Dualistic Model for High-Grade Serous Ovarian Cancer Origins. Lawrenson K, Segato F, Lee J, Pejovic T, Karlan BY, Freedman M, Gayther S, Vavra K, Lin X, Lin Y, Mhawech-Fauceglia P, Rowat AC, Gill NK, Drapkin R, Noushmehr, Hazelett D, Fonseca M, Liu A, Corona R, Dinh H, and Abbasi F.

Promoting food literacy from science to deliciousness. Rowat AC, Soh M, Schmidt L, Jensen L, Malan H, Slusser W.

Tumor-targeted delivery of microRNA-130b, a novel therapeutic strategy for circumventing mutations in p53 by inducing family member TAp63.Gunaratne PH, Rao AK, Hernandez-Herrera A, Pan Y, Rait AS, Benham AL, Rubab F, Venkatanarayan A, Chan CK, Rowat AC, Kim SS, Pirollo KF, Flores ER, Chang EH.

2018


A scalable filtration method for high throughput screening based on cell deformability. Gill NK, Ly C, Nyberg KD, Lee L, Qi D, Tofig B, Sobreiro MR, Dorigo O, Rao JY, Wiedemeyer R, Karlan B, Lawrenson K, Freeman MR, Damoiseaux R, Rowat AC. Lab Chip, in press.

Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function. Kim TH, Ly C, Christodoulides A, Nowell CJ, Gunning PW, Sloan EK, Rowat AC. FASEB J, in press.

Emerin deregulation links nuclear shape instability to metastatic potential (2018) Sobreiro MR, Chen JF, Novitskya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR. Cancer Research, in press. doi: 10.1158/0008-5472.CAN-18-0608

Predicting cancer cell invasion by single-cell physical phenotyping. Nyberg KD, Bruce SL, Nguyen AV, Chan CK, Gill NK, Kim TH, Sloan EK, Rowat AC. Integrative Biol. 10: 218-231. (pdf)

2017


Quantitative deformability cytometry (q-DC): rapid measurements of single cell viscoelastic properties (2017) Nyberg KD, Hu KH, Kleinman SH, Khismatullin DB, Butte MJ, Rowat AC. Biophysical Journal. 113: 1574-1584. (pdf)

Wrinkling of milk skin is mediated by evaporation. Evans AA, Cheung E, Nyberg KD, Rowat AC (2017) Soft Matter. 13: 1056-1062. (pdf)

A protocol for screening cells based on deformability using parallel microfiltration (2017) Gill NK, Qi D, Kim TH, Chan CK, Nguyen AV, Nyberg KD, Rowat AC. Nature Protocol Exchange. (link)

2016


Cancer cells are less deformable and more invasive with activation of β-adrenergic signaling. Kim TH, Gill NK, Nyberg KD, Nguyen AV, Hohlbauch SV, Geisse NA, Nowell CJ, Sloan E, Rowat AC (2016) J Cell Sci. 129: 4563-4575. (pdf)

Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour. Chan CK, Pan Y, Nyberg KD, Lim E, Robertson G, Maar D, Gunaratne PH, Rowat AC (2016) Royal Society Open Biology. 6: 160275. (pdf)

Stiffness of pancreatic cancer cells is associated with increased invasive potential. Nguyen AV, Nyberg KD, Scott MB, Nguyen A, Hohlbauch SV, Geisse NA, Robertson G, Gibb E, Welsh A, Wu N, Donahue T, Rowat AC (2016) Integrative Biology. 8: 1232 – 1245. (pdf)

The physical origins of transit time measurements for rapid, single cell mechanotyping. Nyberg KD, Scott MB, Bruce SL, Gopinath AB, Bikos D, Mason TG, Kim JW, Choi HS, Rowat AC (2016) Lab Chip. 16: 3330 - 3339. (pdf)

Neural regulation of cancer: from mechanobiology to inflammation. Kim TH, Rowat AC*, Sloan E* (2016) Clinical and Translational Immunology. 5: e78. (pdf)

miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Robertson AG, Pan Y, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Chan CK, Chu A, Wen Y, Zhang X, Patil SL, Basu-Roy U, Mansukhani A, Sipahimalani P, Bowlby R, Brooks D, Thiessen N, Ma Y, Moore RA, Schein JE, Mungall AJ, Pecot CV, Sood AK, Jones SJM, Marra MA, Gunaratne P (2016) Oncotarget. 7: 25930-25948. (pdf)

2015


Screening cell mechanotype using parallel microfiltration. Qi D, Gill NK, Santiskulvong C, Dorigo O, Rao J, Taylor-Harding B, Wiedemeyer W, Rowat AC (2015) Sci. Reports. 5: 17595. (pdf)

Physical cell properties that influence migration in confined 3D environments. Lautscham LA, Kämmerer C, Lange J, Kolb T, Mark C, Schilling A, Strissel P, Strick R, Gluth C, Rowat AC, Metzner C, Fabry B (2015) Biophys. J. 109: 1-14. (pdf)

Understanding Fick’s law and diffusion theory through food & cooking. Zhou L, Nyberg K, Rowat AC (2015) Adv. Physiol. Edu. 39: 192–197. (pdf) [Editor’s Pick; Featured in American Physiological Society’s ‘I Spy Physiology’ blog]

A large displacement, high frequency, underwater MEMS actuator. Hoelzle DJ, Chan CK, Scott M, Rowat AC (2015) J. Applied Phys. 117: 014503. (pdf)

Interactive taste tests enhance student learning. Soh M, Roth-Johnson EA, Levis M, Rowat AC (2015) J. Coll. Sci. Teaching. 45: 44-48. (pdf)

2014


The kitchen as a physics classroom. Rowat AC, Sinha NN, Sörensen P, Campàs O, Castells P, Rosenberg D, Brenner MP, Weitz DA (2014) Physics Education, 49: 512-522. (pdf)

A microfluidic technique to probe cell deformability, Hoelzle DJ, Chan CK, Varghese BA, Rowat AC (2014) J. Vis. Expt. 91: e51474. (link)

A new function for Coenzyme Q: A membrane stabilizer? Clarke CF, Rowat AC, Gober JW (2014) Nat. Chem. Biol. 10: 242-243. [News & Views] (pdf)

2013


Elasticity determines shape transitions in soft spheres. Fogle C, Rowat AC, Levine AJ, Rudnick J (2013) Phys. Rev. E., 8: 052404. (pdf)

Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions. Rowat AC*, Jaalouk DE, Zwerger M, Ung L, Eydelnant I, Olins D, Olins A, Herrmann H, Weitz DA, Lammerding J (2013) J. Biol. Chem., 288: 8610-8. (pdf)

The molecules we eat: Food as a medium to communicate science, Rowat AC (2013) Flavour, 2: 10. (pdf)

2012


Parallel fabrication of an array of holes in PDMS. Qi D, Chan CK, Rowat AC* (2012) Lab on a Chip - Chips & Tips. (link)

Probing single cells using flow in microfluidics, Qi D, Hoelzle DJ, Rowat AC* (2012) Eur. Phys. J., 204: 85-101. (pdf)

A microfluidic approach to encapsulate living cells in uniform alginate hydrogel microparticles, Martinez CJ, Kim JW, Ye C, Ortiz I, Rowat AC, Marquez M, Weitz DA (2012) Macromolecular Bioscience, 12: 946-951. (pdf)

2011


The science of chocolate: phase transitions, emulsification, and nucleation, Rowat AC*, Hollar K, Rosenberg D, Stone HA (2011) J. Chem. Edu., 88: 29-33. (pdf)

2010


Divalent cations crosslink vimentin intermediate filament tail domains to regulate network mechanics. Lin YC, Broedersz CP, Rowat AC, Wedig T, Herrmann H, MacKintosh FC, Weitz DA (2010) J. Mol. Biol., 399: 637-44. (pdf)

Ultra high-throughput screening in drop-based microfluidics for directed evolution of highly active peroxidases. Agresti JJ, Antipov E, Abate AR, Ahn K, Rowat AC, Baret JC, Marquez MM, Klibanov AM, Griffiths AD, Weitz DA (2010) Proc. Natl. Acad. Sci., 107: 4004-9. [Featured in ACS Chem. Biol. Spotlight (2010) 5: 261–4; Faculty of 1000 Evaluation; Science Daily] (pdf)

The science of pizza: the molecular origins of cheese, bread, and digestion using interactive activities, Rowat AC*,Hollar K, Rosenberg D, Stone HA (2010) J. Food Sci. Edu., 9:106-112. (pdf)

2009


Understanding epigenetic mechanisms: tracking protein expression across multiple generations of cells. Rowat AC*, Weitz DA (2010) Eur. J. Phys., 178: 71-80. (pdf)

Tracking lineages of cells in lines using a microfluidic device. Rowat AC*, Bird J, Agresti JJ, Rando OJ, Weitz DA* (2009) Proc. Natl. Acad. Sci., 106: 18149-54. (pdf)

Electrodes on a budget: micropatterned electrode fabrication by wet chemical deposition. Ebina W, Rowat AC*, Weitz DA (2009) Biomicrofluidics. 3: 034104. [selected for publication in the Virtual Journal of Biological Physics Research (2009) 18:6] (pdf)

Fabrication of reversibly adherent fluidic devices by magnet adhesion. Rafat M, Raad D, Rowat AC, Auguste DT (2009) Lab on a Chip. 9: 3016-9. (pdf)

Dropspots: a picoliter array in a microfluidic device. Schmitz C, Rowat AC*, Köster S, Weitz DA* (2009) Lab on a Chip, 9: 44-49. (pdf)

Physical properties of the cell nucleus studied by micropipette aspiration. Rowat AC* (2009) in The Nucleus: Volume 2: Chromatin, Transcription, Envelope, Proteins, Dynamics, and Imaging. Ed. Hancock, R. Totowa, USA: Humana Press. 464: 3-12. (pdf)

2008


Biocompatible surfactants for water-in-fluorocarbon emulsions. Holtze C, Rowat AC, Agresti JJ, Hutchison B, Angilè FE, Köster S, Duan H, Schmitz C, Humphry KJ, Pisignano D, Weitz DA (2008) Lab on a Chip. 8: 1632-9. [highlighted in Chemical Technology] (pdf)

Modular drop-based microfluidic devices for single cell studies. Köster S, Angilè FE, Duan H, Agresti JJ, Wintner A, Schmitz C, Rowat AC, Merten CA, Pisignano D, Griffiths AD, Weitz DA (2008) Lab on a Chip. 8: 1110 – 5. (pdf)

Influence of ethanol on lipid membranes: from lateral pressure profiles to dynamics and partitioning. Terama E, Ollila OHS, Salonen E, Rowat AC, Trandum C, Westh P, Patra M, Karttunen M, Vattulainen I (2008) J. Phys. Chem. B. 112: 4131-4139.

How to easily punch holes in a PDMS microfluidic device. Rowat AC*, Weitz DA (2008) Lab on a Chip - Chips & Tips. (link)

Towards an integrated understanding of the structure and mechanics of the cell nucleus. Rowat AC*, Lammerding J, Herrmann H, Aebi U (2008) BioEssays. 30: 226-36. (pdf)

Controlled emulsions: fabrication and applications. Shah RK, Shum HC, Rowat AC, Lee D, Agresti JJ, Utada AS, Chu LY, Kim JW, Fernandez-Nieves A, Martinez CJ, Weitz DA (2008) Materials Today. 11: 18-27. (pdf)

2007


The cell as a material. Kasza KE, Rowat AC, Liu J, Angelini TE, Brangwynne CP, Koenderink GH, Weitz DA (2007) Curr. Opin. Cell Biol. 19:101-7. (pdf)

2006


Mechanics of the cell nucleus and effects of emerin deficiency. Rowat AC*, Lammerding J, Ipsen JH (2006) Biophys. J. 91:4649-64. (pdf)

Universal behaviour of membranes with sterols. Henriksen JH, Rowat AC, Brief E, Hsueh YW, Thewalt JL, Zuckermann MJ, Ipsen JH (2006) Biophys. J. 90: 1639-49. (pdf)

Interactions of oleic acid and model stratum corneum membranes as seen by 2H-NMR. Rowat AC, Kitson N, Thewalt JL (2006) J. Int. Pharm. 307:225-31. (pdf)

< 2005


Effects of farnesol on the physical properties of DMPC membranes. Rowat AC, Keller D, Ipsen JH (2005) Biochim. Biophys. Acta. 1713: 29-39. (pdf)

Characterization of the elastic properties of the nuclear envelope. Rowat AC, Foster LJ, Nielsen MM, Weiss M, Ipsen JH (2005) J. Roy. Soc. Interface. 2: 63-9. [highlighted in J. Exp. Biol. (2005) 208:vii] (pdf)

Farnesylated peptides in model membranes: a biophysical investigation. Rowat AC, Brask J, Sparrmann T, Jensen KJ, Lindblom G, Ipsen JH (2004) Eur. Biophys. J. 33: 300-9. [Erratum in Eur Biophys J. 2004 Oct;33(6):562-3.] (pdf)

Farnesol-DMPC phase behaviour: a 2H-NMR study. Rowat AC, Davis JH (2004) Biochim. Biophys. Acta 661: 178-87. (pdf)

Experimental evidence of the electrostatic contribution to membrane bending rigidity. Rowat AC, Hansen PL, Ipsen JH (2004) Europhys. Lett. 67: 144-9. (pdf)

Vesicle fluctuation analysis of the effects of sterols on membrane bending rigidity. Henriksen JH, Rowat AC, Ipsen JH (2004) Eur. Biophys. J. 33: 732-41. (pdf)

Brillouin light scattering studies of the mechanical properties of polystyrene/polyisoprene multilayered thin films. Forrest J, Rowat AC, Dalnoki-Veress K, Stevens JR, Dutcher JR (1996) Journal of Polymer Science: Part B: Polymer Physics. 34: 3009-16.

Brillouin light scattering determination of the glass transition in thin, freely-standing polystyrene films. Forrest J, Dalnoki-Veress K, Dutcher JR, Rowat AC, Stevens JR (1996) Mater. Res. Soc. Symp. 407: 131-6.

* = corresponding author, = equal contribution
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