Mark Frye


phone:  (310) 825-5360

office:  2014 TLSB


research interests:  Neural circuits for visual and olfactory behavior

Research Interests

General introduction How are flexible and robust animal behaviors orchestrated by the nervous system? Different forms of this general question have occupied neuroscientists for decades. Great strides have been made toward describing the elements of nervous system development, structure, and function. Our next challenge is to examine how behavior emerges from the interactions among genetic, cellular, cell-system, and organ-system levels of organization. My laboratory studies these interactions in a powerful model system ? the fruit fly Drosophila melanogaster. Whereas research with Drosophila is most often focused within the molecular-genetic spectrum of modern biology, this animal also shows remarkable behavioral performance, making its living navigating vast distances through complex visual landscapes in search of the source of an attractive odor. A fly?s sophisticated navigation capabilities emerge from the fusion of multiple sensory modalities and transformation of a robust motor code. By combining the rapidly expanding toolkit of fruit fly molecular genetics with live imaging and 'virtual reality' behavioral techniques, we hope to reveal the functional mechanisms and structural circuits with which the fly brain coordinates the biomechanics and dynamics of complex sensory behavior. The results of this cross-disciplinary approach could have broad impact on our understanding of the general principles of sensory fusion and sensory-motor integration common among animal taxa, and also motivate specialized technical advances in bio-inspired robotic devices.

Selected Publications

Frye MA, "Insect vision: a neuron that anticipates an object?s path", Current Biology, 27 : R1076-1078 (2018) .

Mongeau JM, Frye MA, "Flies spatio-temporally integrate visual signals to control saccades", Current Biology, 27 (9): 2901-2914 (2017) .

Omoto JJ, Keles MF, Nguyen B-CM, Bolanos C, Lovick JK, Frye MA, Hartenstein V, "Visual input to the Drosophila central complex by developmentally and functionally distinct neuronal populations", Current Biology, 27 (8): 1098-1110 (2017) .

Keles MF, Frye MA, "The eyes have it", eLife, 6:e24896 : (2017) .

Keles MF, Frye MA, "Object detecting neurons in Drosophila", Current Biology, 27 (5): 680-687 (2017) .

Wasserman SW, Frye MA, "Group Behavior: Social context modulates behavioral responses to sensory stimuli", Curr Biol, 25 : R448-469 (2015) .

Aptekar JW, Keles MF, Lu PM, Zolotova NM, Frye MA, "Neurons forming optic glomeruli compute figure-ground discriminations", J Neuroscience, 35 : 7587-7599 (2015) .

Frye MA, "Quick guide: Elementary motion detectors", Curr Biol, 25 : R215-217 (2015) .

Wasserman SW, Aptekar JW, Lu PM, Nguyen J, Wang AL, Keles MF, Grygoruk A, Krantz DE, Larsen C, Frye MA, "Olfactory neuromodulation of motion vision circuitry in Drosophila", Curr Biol, 25 : 467-472 (2015) .

Aptekar JW, Keles M, Mongeau JM, Lu P, Frye MA, Shoemaker PS, "Method and software for using m-sequences to characterize parallel components of higher-order visual tracking behavior in Drosophila", Front Neural Circuits, (2014) [link].