phone: (310) 825-5360
office: 2014 TLSB
research interests: Integrative physiology of insect flight.
General introduction How are flexible and robust animal behaviors orchestrated by the nervous system? Different forms of this general question have occupied neuroscientists for decades. Great strides have been made toward describing the elements of nervous system development, structure, and function. Our next challenge is to examine how behavior emerges from the interactions among genetic, cellular, cell-system, and organ-system levels of organization. My laboratory studies these interactions in a powerful model system ? the fruit fly Drosophila melanogaster. Whereas research with Drosophila is most often focused within the molecular-genetic spectrum of modern biology, this animal also shows remarkable behavioral performance, making its living navigating vast distances through complex visual landscapes in search of the source of an attractive odor. A fly?s sophisticated navigation capabilities emerge from the fusion of multiple sensory modalities and transformation of a robust motor code. By combining the rapidly expanding toolkit of fruit fly molecular genetics with state-of-the-art engineering techniques, we hope to reveal the functional mechanisms and structural circuits with which the fly brain coordinates the biomechanics and dynamics of complex behavior. The results of this cross-disciplinary approach could have broad impact on our understanding of the general principles of sensory fusion and sensory-motor integration common among animal taxa, and also motivate specialized technical advances in bio-inspired robotic devices. Sensory fusion and sensorimotor integration in Drosophila Whereas visual motion processing and olfactory discrimination have been studied independently and in great depth in several prominent model systems including fruit flies, how these sensory cues are integrated to modify the motor control of behavior has received less attention. My laboratory approaches this challenge by combining behavioral, psychophysical, electrophysiological, and genetic techniques. We focus on three broad questions: (1) How are variations in the spatial and temporal structure of the visual world transformed into motor commands for walking or flight? (2) How are motor commands influenced by the integration or ?fusion? of input from multiple sensory modalities? (3) What are the physiological mechanisms and anatomical loci of multi-sensory fusion and sensory-motor integration? To address these questions, we integrate four complimentary experimental techniques: (1) electronic ?virtual reality? flight simulators for individual animals operating under natural feedback conditions, (2) a visual ?treadmill? outfitted with a real-time video tracking system that monitors the spatial distribution of large groups of waling flies in response to visual, thermal, or olfactory stimuli, (3) electrophysiological recordings from the central nervous system and flight muscles, and (4) molecular-genetics to target the expression of reporter and effector genes within the brain.
Wasserman S, Lu P, Aptekar JW, Frye MA, "Flies dynamically anti-track, rather than ballistically escape, aversive odor during flight", J. Exp. Biol, 215 : 2833-2840 (2012) .
Duistermars BJ, Care RA, Frye MA, "Binocular interactions underlying the classic optomotor response in flying flies", Front. Beh. Neurosci, 6 (6): (2012) [link].
Aptekar JW, Shoemaker PA, Frye MA, "Figure tracking by flies is supported by parallel visual streams", Curr. Biol, 22 : 482-487 (2012) .
Chow DC, Theobald JC, Frye MA, "An olfactory circuit increases the fidelity of visual behavior", J. Neurosci, 31 : 15035-15047 (2011) .
Krishnan P, Duistermars BJ, Frye MA, "Odor identity influences tracking of temporally patterned plumes in Drosophila", BMC Neurosci, 12 (62): (2011) [link].
Paydar OH, Chung A, Nikham D, Fung AO, Matthews B, Judy JW, Frye MA, Markovic D, "MEMS-enabled multi-unit recording from Drosophila melanogaster", Proceedings IEEE 24th International Conference, (2011) .
Theobald, J.C., Shoemaker, P.A., Ringach, D.L., and Frye, M.A., "Theta motion processing in fruit flies", Frontiers in Behavioral Neuroscience, 35 : (2010) .
Frye, M.A., "Multisensory systems integration for high-performance motor control in flies", Current Opinion in Neurobiology, Kristin Scott(Eds.), 20 : 347-353 (2010) .
Gomez-Martin, A., Duistermars, B.J., Frye, M.A., and Louis, M., "Mechanisms of odor tracking: multiple sensors for enhanced perception and behavior", Frontiers in Cellular Neuroscience, 4 (6): (2010) .
Theobald, J.C., Ringach, D.L., and Frye, M.A., "Visual stabilization dynamics are enhanced by standing flight velocity", Biology Letters, 6 (410): 413- (2010) .