phone: (310) 206-6636
office: 2024 TLSB
research interests: Neuronal Mechanisms Controlling Jaw Movement
My global interest is in how the central nervous system controls movement. Precisely how we produce coordinated, rhythmical movements such as locomotion, mastication, and respiration is a fundamental problem in neuroscience that is poorly understood. During injury or disease these basic types of movements, which we take for granted, can be compromised. My lab uses animal models to study how rhythmical jaw movements are produced. We use a combination of electrophysiological, molecular, pharmacological techniques in conjunction with computational modeling to address basic questions about how single and small networks of neurons in the brainstem orchestrate coordinated activity in synapses and ion channels to produce unique discharge patterns that occur during rhythmical movements. We have found that localized groups of neurons within small areas of the brainstem are important for the basic rhythmical component of mastication and that specific ion channels are activated to produce the appropriate discharge patterns reminiscent of masticatory patterns. More recently, the lab has obtained transgenic mice that produce the majority of symptoms of the devastating disease, Amyotrophic Lateral Sclerosis (ALS), otherwise known as Lou Gehrig?s disease. We found that certain ion channels in both sensory and motoneurons are abnormally active prior to the onset of symptoms of the disease. Although these studies are in the early stages, they could provide insight into how the motoneuronal neurodegeneration that is responsible for paralysis and death occur, and will start to identify new molecular targets for development of rational drug therapies to delay motoneuronal degeneration and prolong the life of ALS patients.
Salomon D., Martin-Harris., Mullen B., Odegaard B., ZvinyatskovskiyA., and Chandler S.H, "Brain Literate: Making Neuroscience Accessible to a Wider Audience of Undergraduates", J. Undergraduate Neurosci. Educ, 13 : 1-9 (2015) .
Masoumi A., Low E., Shoghi T., Chan P., Hsiao CF., Chandler S.H., & Martina Wiedau-Pazos., "Enrichment of human embryonic stem cell derived motor neuron cultures using arabinofuranosyl cytidine", Future Neurol, 10 : 91-99 (2015) .
Venugopal S., Hsiao CF., Sonoda T., Weidau-Pazos M.,and Chandler S.H., "Homeostatic dysregulation in membrane properties of masticatory motoneurons compared to oculomotor neurons in a mouse model for Amyotrophic Lateral Sclerosis", J. Neurosci, 35 : 707-720-720 (2015) .
Tsuruyama K, Hsiao CF, Chandler SH, "Participation of a persistent sodium current and calcium-activated nonspecific cationic current to burst generation in trigeminal principal sensory neurons", J. Neurophysiology, 110 : 1903-1914 (2013) .
Hsiao CF, Kaur G, Vong A, Bawa H, Chandler SH, " Participation of Kv1 channels in control of membrane excitability and burst generation in mesencephalic V neurons", J. Neurophysiology, 101 : 1407-1418 (2009) .
Hsiao, C.F., Gougar, K., Asai, J. and Chandler, S.H, " Intrinsic membrane properties and morphological characteristics of interneurons in the rat supratrigeminal region", J.Neurosci. Res, 85 : 3673-3686 (2007) .
Enomoto, A., Han, J.M., Hsiao, C.F. and Chandler, S.H., "Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice,", J Neurophysiol, 98 : 710-719 (2007) .
Enomoto, A., Han, J.M., Hsiao, C.F., Wu, N. and Chandler, S.H., "Participation of sodium currents in burst generation and control of membrane excitability in mesencephalic trigeminal neurons", J Neurosci, 26 : 3412-3422 (2006) .
Tanaka, S. and Chandler, S.H., "Serotonergic modulation of persistent sodium currents and membrane excitability via cyclic AMP-protein kinase A cascade in mesencephalic V neurons", J Neurosci Res, 83 : 1362-1372 (2006) .
Starling, A.J., Andre, V.M., Cepeda, C, de Lima, M., Chandler, S.H. and Levine, M.S., "Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease", J. Neurosci. Res, 82 : 377-386 (2005) .