office: 4303A LS
research interests: The role of diet and exercise in the prevention and control of degenerative diseases.
I am primarily interested in studying adaptations associated with exercise and diet that might explain their protective effects. My major areas of interest at the present time include the value of diet and exercise as preventive measures for heart disease and cancer. Studies in my laboratory range from the molecular level to the whole organism. Most of the research focuses on changes in serum factors following diet and/or exercise intervention and their impact on cells grown in culture. We also use normal and transgenic mice for diet experiments related to cancer. I have been studying diet and exercise for over 40 years and am convinced that most of the health problems seen in the U.S. and other industrialized countries are the result of poor diet, a lack of regular exercise and exposure to hazardous chemicals.
Leung, P-S., W.J. Aronson, T.H. Ngo, L.A. Golding and R.J. Barnard, "Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro", J. Appl. Physiol, 96 : 450-454 (2004) .
Molteni, R., A. Wu, S. Vaynman, Z. Ying, R.J. Barnard, F. Gomez-Pinella., "Exercise reverses the harmful effects of consumption of a saturated-fat diet on synaptic and behavioral plasticity associated to the action of BDNF", Neuroscience, 123 : 429-440 (2004) .
Barnard, R.J. and Aronson, W.J., "Diet, Exercise and Prostate Cancer", Prostate Cancer, J.N. Lucas(Eds.), Chapt. 1 : (2004) .
Ngo, T.H., R.J. Barnard, T. Anton, C. Tran, D. Elashoff, D. Heber, S.J. Frieedland, W.J. Aronson, "Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence", Cancer Res, 64 : 1252-1254 (2004) .
Wegge, J.K., C.K. Roberts, T.H. Ngo and R.J. Barnard, "Effect of diet and exercise intervention on inflammatory markers of atherosclerosis in postmenopausal women", Metabolism, 53 : 377-381 (2004) .
Ngo, T.H., R.J. Barnard, P. Cohen, S. Freedland, C. Tran, F. deGregorio, Y.I. Elshimal, D. Heber, W.J. Aronson, "Effect of isocaloric low-fat diet on human LAPC-4 prostate xenografts in SCID mice and the IGF axis", Clin. Cancer Res, 9 : 2734-2743 (2003) .
Roberts, C.K. and R.J. Barnard, "Low-carbohydrate diets as compared with low-fat diets", New Engl. J. Med, 349 : 1000- (2003) .
Ngo, T.H., R.J. Barnard, P. Cohen and W.J. Aronson., "IGF-1 and Insulin-like growth factor binding protein-1 (IGFBP-1) modulate prostate cancer cell growth and apoptosis: Possible mediators for the effects of diet and exercise on cancer cell survival", Endocrinology, 144 : 2319-2324 (2003) .
Barnard, R.J., T.H. Ngo, W.J. Aronson and L.A. Golding, "A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro", Prostate, 56 : 201-206 (2003) .
Barnard, R.J. and J.O. Holloszy, "The metabolic systems: Aerobic metabolism and substrate untilization in exercising skeletal muscle", The History of Exercise Physiology, C.M. Tipton(Eds.), 292-320 (2003) .