office: CHS 27-200K CHS
research interests: Gene regulation, metabolism, diabetes, and nutrient sensing
B.A. , Biology, California State University, San Bernardino 2001
PhD, Lipid Biochemistry, University of California, San Francisco 2007
We are interested in understanding how cells sense and control metabolism in response to stressors like temperature. The ability to maintain a constant body temperature despite a changing environment can lead to dramatic changes in energy expenditure. This requires an understanding of integrative metabolism and physiology. Our lab will explore the molecular mechanisms that promote energy expenditure. These studies will provide opportunities for intervening in metabolic diseases that are associated with obesity. https://sites.lifesci.ucla.edu/ibp-villanuevalab/
Anthony RP Verkerke, Patrick J Ferrara, Chien-Te Lin, Jordan M Johnson, Terence E Ryan, J Alan Maschek, Hiroaki Eshima, Christopher W Paran, Brenton T Laing, Piyarat Siripoksup, Trevor S Tippetts, Edward J Wentzler, Hu Huang, Espen E Spangenburg, Jeffrey J Brault, Claudio J Villanueva, Scott A Summers, William L Holland, James E Cox, Dennis E Vance, P Darrell Neufer, Katsuhiko Funai., "Phospholipid methylation regulates muscle metabolic rate through Ca 2+ transport. efficiency", Nature Metabolism, 1 : 876-885 (2019) .
Charisse Petersen, Rickesha Bell, Kendra A Klag, Soh-Hyun Lee, Raymond Soto, Arevik Ghazaryan, Kaitlin Buhrke, H Atakan Ekiz, Kyla S Ost, Sihem Boudina, Ryan M O'Connell, James E Cox, Claudio J Villanueva, W Zac Stephens, June L Round., "T cell-mediated regulation of the microbiota protects against obesity", Science, 365 (6451): (2019) .
Gisela Geoghegan, Judith Simcox, Marcus M Seldin, Timothy J Parnell, Chris Stubben, Steven Just, Lori Begaye, Aldons J Lusis, Claudio J Villanueva., "Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism", Molecular Metabolism, 24 : 44-63 (2019) .
Stephanie Pearson, Anne Loft, Prashant Rahbhandari, Judith Simcox, Sanghoon Lee, Peter Tontonoz, Susanne Mandrup, Claudio J Villanueva., "Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism", Genes & Development, (2019) .
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O'Connell., "Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease", PLOS Genetics, 15 (2): (2019) .
Gilles Storelli, Hyuck-Jin Nam, Judith Simcox, Claudio J Villanueva, Carl S Thummel., "Drosophila HNF4 directs a switch in lipid metabolism that supports the transition to adulthood", Developmental Cell, 48 (2): 200-214 (2019) .
Simon T Bond, Sarah C Moody, Yingying Liu, Mete Civelek, Claudio J Villanueva, Paul Gregorevic, Bronwyn A Kingwell, Andrea L Hevener, Aldons J Lusis, Darren C Henstridge, Anna C Calkin, Brian G Drew., "The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes", American Journal of Physiology-Endocrinology and Metabolism, 316 (2): E293-E304 (2018) .
Santhosh Karanth, JD Adams, Maria de los Angeles Serrano, Ezekiel B Quittner-Strom, Judith Simcox, Claudio J Villanueva, Lale Ozcan, William L Holland, H Joseph Yost, Adrian Vella, Amnon Schlegel., "A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose", Cell Reports, 24 (2): 312-319 (2018) .
Judith Simcox, Gisela Geoghegan, John Alan Maschek, Claire L Bensard, Marzia Pasquali, Ren Miao, Sanghoon Lee, Lei Jiang, Ian Huck, Erin E Kershaw, Anthony J Donato, Udayan Apte, Nicola Longo, Jared Rutter, Renate Schreiber, Rudolf Zechner, James Cox, Claudio J Villanueva, "Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis", Cell Meetabolism, 26 (3): 509-522 (2017) .