office: 1014 TLSB
research interests: Sleep regulatory mechanisms
My work examines the genetic regulation of sleep and more importantly, how genetic heterogeneity influences the ability to recover from sleep loss. My research program currently has two foci: 1) to determine if disruptions of biological timing result in sleep-wake disorders and if so, which specific genes are involved and, 2) to determine if sex differences in the risk and severity of sleep abnormalities are chromosomally driven. My lab has recently undertaken a forward genetics approach to identify novel sleep genes. We have characterized a variety of sleep phenotypes in inbred mouse strains in sleep-replete and sleep-deprived conditions. We are expanding this dataset to provide sufficient statistical power for quantitative trait loci (QTL) analysis and subsequent follow-up studies. This endeavor combines a well-established paradigm of comparative phenotyping of a genetically tractable animal model with powerful genetic mapping tools to identify novel sleep-regulatory genes. Consequently, these experiments will not only identify new sleep genes, they will also help verify and clarify previously mapped genes whose roles are not yet clearly defined.
Ehlen, J.C., Brager, A.j., Baggs, J., Pinckney, L., Debruyne, J.P., Esser, K.A., Takahashi, J.S., Paul, K.N., "Bmal1 function in skeletal muscle regulates sleep", eLife, 1-15 (2017) .
Clark, K.P., Ehlen, J.C., Paul, K.N., "Race and Gender Disparities in Sleep-Disordered Breathing", Journal of Sleep Disorders: Treatment & Care, 6 (1): 1-4 (2017) .
Brager A.J., Heemstra, L., Bhambra, R., Ehlen, J.C., Esser, K., Paul, K.N., Novak, C. M., "Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal muscle clock", Biochimie, 132 : 161-165 (2017) .
Brager, A.J., Yang, T., Ehlen, J.C., Simon, R.P., Meller, R., Paul, K.N., "Limb-derived ischemia improves stroke outcome by promoting sleep", Sleep, 39 : 2033-2040 (2016) .
Ehlen, J.C., Jones, K.A., Pinckney, L., Burette, S., Weinberg, R.J., Evans, J.A., Brager, A., Zylka, M.J., Paul, K.N., Philphot, B.D., Debruyne, J.P, "Maternal Ube3a loss disrupts sleep homeostasis but leaves circadian rhythmicity largely intact", Sleep, 35 : 13587-13598 (2015) .
Evans, J.A., Suen, T-C., Calif, B., Mitchell, A., Castanon-Cervantes, O., Baker, K.M., Kloehn, I., Baba, K., Teubner, B.J.W., Ehlen, J.C., Paul, K.N., Bartness, T.J., Tosini, G., Leise, T.L., Davidson, A.J, "Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body", Sleep, 13 : 1-15 (2015) .
Jefferson, F., Ehlen, J.C., Williams, N.S., Paul, K.N, "A dopamine D2-receptor agonist attenuates the ability of stress to alter sleep in mice", Sleep, 155 : 4411-4421 (2014) .
Ehlen, J.C., Benveniste, M., Brager, A.J., Pinckney, L., Jefferson, F., Paul, K.N., "Period-amplitude analysis reveals wake-dependent changes during sleep deprivation. Sleep", Sleep, 36 : 1723-1735 (2013) .
Brager, A.J., Ehlen, J.C., Castanon-Cervantes, O., Natarajan, D., Delisser, P., Davidson, A., Paul, K.N, "Sleep loss and inflammatory markers under chronic environmental circadian disruption", Sleep, 8 : 1-8 (2013) .
Ehlen, J.C., Hesse S., Pinckney, L., Paul, K.N, "Sex chromosomes regulate nighttime sleep propensity during recovery from sleep loss", Sleep, 8 : 1-6 (2013) .