Stephanie Correa

email:  STEPHANIECORREA@UCLA.EDU

phone:  5-1559

office:  2032 Terasaki Life Sciences

homepage:  http://www.correalab.org

research interests:  Neural control of energy homeostasis, estrogen signaling, neuroendocrinology

Education

B.A., Biology, Pomona College 2000
Ph.D., Neurobiology & Behavior, Cornell University 2007

Research Interests

My lab is broadly interested in understanding how reproductive hormones affect metabolic health and disease. In women, high estrogen suppresses energy intake and promotes energy expenditure. Low estrogen levels after menopause can result in weight gain that can be rescued by estrogen treatment. Our research aims to provide a mechanistic framework for how estrogen promotes metabolic health. To understand the mechanisms by which estrogen alters metabolism, we focus on the following broad questions: How does the brain regulate energy intake and expenditure? How do metabolic neural circuits differ between males and females? How are they modulated by reproductive hormones? We use genetically engineered mice and new viral tools to define the neurons that drive estrogen-responsive and sex-specific changes in energy balance. This approach allows us to dissect the effects of estrogen on distinct neuronal populations with spatial, molecular, and temporal specificity. Ultimately, we hope to identify avenues for developing targeted, non-hormonal treatments for obesity.


Selected Publications

Correa, S. M., Newstrom, D. W., Warne J. P., Flandin, P., Cheung, C. C., Pierce, A. A., Lin-Moore, A. T., Xu, A. W., Rubenstein, J. L. and H. A. Ingraham, "An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females", Cell Reports, 10 : 62-74 (2015) [link].

Correa, S. M., Washburn, L. L., Kahlon, R. S., Musson, M. C., Bouma, G. J., Eicher, E. M. and Albrecht, K. H., "Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway", PLoS Genetics, 8 (4): 1002569-1002588 (2012) [link].

Correa, S. M., Horan, C. M., Johnson, P. A., Adkins-Regan, E., "Copulatory Behaviors and Body Condition Predict Post-Mating Female Hormone Levels, Fertilization Success, and Primary Sex Ratios in Japanese Quail", Hormones and Behavior, 59 : 556-564 (2011) [link].

Correa, S. M., Adkins-Regan, E., and Johnson, P. A., "High Progesterone During Avian Meiosis Biases Sex Ratios Toward Females", Biology Letters, 1 : 215-218 (2005) [link].