Stephanie Correa

email:  STEPHANIECORREA@UCLA.EDU

phone:  5-1559

office:  2028 Terasaki Life Sciences

homepage:  http://www.correalab.org

research interests:  Neural control of energy homeostasis, estrogen signaling, neuroendocrinology

Education

B.A., Biology, Pomona College 2000
Ph.D., Neurobiology & Behavior, Cornell University 2007

Research Interests

My lab is broadly interested in understanding how reproductive hormones affect temperature and energy balance. In women, the menopausal transition is associated with hot flashes and increased visceral body fat. Our research aims to understand how estrogens act on the hypothalamus to alter temperature homeostasis and metabolic health. These studies can help us better understand weight gain and hot flashes in postmenopausal women. To understand the mechanisms by which estrogen alters the homeostasis, we focus on the following broad questions: How does the brain regulate temperature and energy balance? How do homeostatic neural circuits differ between males and females? How are homeostatic circuits modulated by estrogens? We use genetically engineered mice and new viral tools to define the neurons that drive estrogen-responsive and sex-specific changes in energy balance. This approach allows us to dissect the effects of estrogen on distinct neuronal populations with spatial, molecular, and temporal specificity. Ultimately, we hope to identify avenues for developing targeted, non-hormonal treatments for hot flashes and obesity.


Selected Publications

Lee, S. D., Priest, C., Bjursell, M., Gao, J., Arneson, D. V., Ahn, I. S., Diamante, G., van Veen, J. E., Massa, M. G., Calkin, A. C., Kim, J., Anders?n, H., Porritt, M., Carreras, A., Ahnmark, A., Seeliger, F., Maxvall, I., Eliasson, P., Althage, M., ?kerblad, P., Lind?n, D., Cole, T. A., Lee, R., Boyd, H., Bohlooly-Y, M., Correa, S. M., Yang, X., Tontonoz, P., and Hong, C., "IDOL regulates systemic energy balance through control of CNS VLDLR expression", Nature Metabolism, (2019) .

Candice B. Herber, William C. Krause, Liping Wang, James R. Bayrer, Alfred Li, Matthew Schmitz, Aaron Fields, Breanna Ford, Zhi Zhang, Michelle S. Reid, Daniel K Nomura, Robert A. Nissenson, Stephanie M. Correa*, and Holly A. Ingraham*, "Estrogen Signaling in Arcuate Kiss1 Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice", Nature Communications, 10 : 163- (2019) .

Correa, S. M., Newstrom, D. W., Warne J. P., Flandin, P., Cheung, C. C., Pierce, A. A., Lin-Moore, A. T., Xu, A. W., Rubenstein, J. L. and H. A. Ingraham, "An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females", Cell Reports, 10 : 62-74 (2015) [link].

Correa, S. M., Washburn, L. L., Kahlon, R. S., Musson, M. C., Bouma, G. J., Eicher, E. M. and Albrecht, K. H., "Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway", PLoS Genetics, 8 (4): 1002569-1002588 (2012) [link].

Correa, S. M., Horan, C. M., Johnson, P. A., Adkins-Regan, E., "Copulatory Behaviors and Body Condition Predict Post-Mating Female Hormone Levels, Fertilization Success, and Primary Sex Ratios in Japanese Quail", Hormones and Behavior, 59 : 556-564 (2011) [link].

Correa, S. M., Adkins-Regan, E., and Johnson, P. A., "High Progesterone During Avian Meiosis Biases Sex Ratios Toward Females", Biology Letters, 1 : 215-218 (2005) .