office: 3825A MSB
research interests: Microbiome, Neurobiology of Disease, Neuroimmunology, Host-Microbe Interactions
Our bodies are comprised of around ten times more microbial cells than human eukaryotic cells, and more and more, we are learning that these microbes that make up ?us? play a fundamental role in regulating brain development and function, and behavior. Microbes modulate host levels of neuroactive molecules, including neurotransmitters and neuropeptides, as well as complex behaviors, such as social, communicative, emotional and anxiety-like behaviors. Alterations in the microbial communities that inhabit us are further implicated in a variety of neurological disorders, including autism, depression and Parkinson's disease. Situated at the interface of neurobiology, immunology and microbiology, we are using integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?
Jameson K. G., Hsiao E. Y., "A novel pathway for microbial metabolism of Levodopa", Nature Medicine, (2019) [link].
Hsiao E. Y., "The neuroimmune collective, in "Voices: The Next Quarter Century"", Immunity, 50 : 769-777 (2019) .
Vuong H. E., Hsiao E. Y., "Gut microbes join the social network", Neuron, 101 : 196-198 (2019) .
Ahn I., Lang J., Olson C. A., Ying Z., Zhang G., Byun H., Zhao Y., Kurt Z., Lusis A. J., Hsiao E. Y., Gomez-Pinilla F., Yang X., "Host genetic background and gut microbiota contribute to differential metabolic responses to high fructose consumption in mice", BioRxiv, (2019) [link].
Labus J. S., Osadchiy V., Hsiao E. Y., Tap J., Derrien M., Gupta A,, Tillisch K., Le Neve B., Grinsvall C., Ljungberg M., Ohman L., Tornblom H., Simren M., Mayer E. A., "Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis", Microbiome, 7 : 45- (2019) .
Fields C., Sampson T., Bruce-Keller A., Kiraly D., Hsiao E. Y., De Vries G., "Defining dysbiosis in disorders of movement and motivation", Journal of Neuroscience, (2018) .
Lee K., Vuong H. E., Nusbaum D. J., Hsiao E. Y., Evans C. J., Taylor A. M. W., "The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence", Neuropsychopharmacology, (2018) [link].
Olson C. A., Vuong H. E., Yano J. M., Liang Q. Y., Nusbaum D. J., Hsiao E. Y., "The gut microbiota mediates the anti-seizure effects of the ketogenic diet", Cell, 173 : 1728-1741 (2018) .
Osadchiy V., Labus J. S., Jacobs J., Gupta A., Ashe-MacNalley C., Hsiao E. Y., Mayer E. A., "Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects", PLoS One, 13 (e0201772): 1-16 (2018) .
Kentner A., Bilbo S., Brown A., Hsiao E. Y., McAllister K., Meyer U., Pearce B., Pletnikov M., Yolken R., Bauman M., "Maternal Immune Activation: Reporting guidelines to improve the rigor, reproducibility and transparency of the model", Neuropsychopharmacology, (2018) .