Elaine Hsiao

email:  ehsiao@g.ucla.edu

office:  3825A MSB

homepage:  http://hsiao.science

research interests:  Microbiome, Neurobiology of Disease, Neuroimmunology, Host-Microbe Interactions

Research Interests

Our bodies are comprised of around ten times more microbial cells than human eukaryotic cells, and more and more, we are learning that these microbes that make up ?us? play a fundamental role in regulating brain development and function, and behavior. Microbes modulate host levels of neuroactive molecules, including neurotransmitters and neuropeptides, as well as complex behaviors, such as social, communicative, emotional and anxiety-like behaviors. Alterations in the microbial communities that inhabit us are further implicated in a variety of neurological disorders, including autism, depression and Parkinson's disease. Situated at the interface of neurobiology, immunology and microbiology, we are using integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?

Selected Publications

Fields C., Sampson T., Bruce-Keller A., Kiraly D., Hsiao E. Y., De Vries G., "Defining dysbiosis in disorders of movement and motivation", Journal of Neuroscience, (2018) .

Lee K., Vuong H. E., Nusbaum D. J., Hsiao E. Y., Evans C. J., Taylor A. M. W., "The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence", Neuropsychopharmacology, (2018) [link].

Olson C. A., Vuong H. E., Yano J. M., Liang Q. Y., Nusbaum D. J., Hsiao E. Y., "The gut microbiota mediates the anti-seizure effects of the ketogenic diet", Cell, 173 : 1728-1741 (2018) .

Osadchiy V., Labus J. S., Jacobs J., Gupta A., Ashe-MacNalley C., Hsiao E. Y., Mayer E. A., "Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects", PLoS One, 13 (e0201772): 1-16 (2018) .

Kentner A., Bilbo S., Brown A., Hsiao E. Y., McAllister K., Meyer U., Pearce B., Pletnikov M., Yolken R., Bauman M., "Maternal Immune Activation: Reporting guidelines to improve the rigor, reproducibility and transparency of the model", Neuropsychopharmacology, (2018) .

Hsiao, E. Y. as a member of: National Academies of Sciences, Engineering and Medicine; Committee on Advancing Understanding of the Implications of Environmental-Chemical Interactions with the Human Microbiome, "Environmental Chemicals, the Human Microbiome and Health Risk: A Research Strategy", The National Academies Collection: Reports funded by the National Institutes of Health, (2018) [link].

Hsiao E. Y., "Decoding states and contexts, in "Setting the Stage for the Next Generation of Neuroscience"", Neuron, 99 : 11-12 (2018) .

Jameson K. G., Hsiao E. Y., "Linking the gut microbiome to a brain neurotransmitter", Trends in Neuroscience, 41 : 413-414 (2018) .

Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna R, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA, "Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome", Microbiome, 5 (49): 1-17 (2017) .

Labus J. S., Hsiao E. Y., Tap J., Derrien M., Gupta A., Le Neve B., Brazeilles R., Grinsvall C., Ohman L., Tornblom H., Tillisch K., Simren M., Mayer E. A., "Clostridia from the gut microbiome are associated with brain functional connectivity and evoked symptoms in IBS", Gastroenterology, 152 : S40- (2017) .