office: 3825A MSB
research interests: Microbiome, Neurobiology of Disease, Neuroimmunology, Host-Microbe Interactions
Our bodies are comprised of around ten times more microbial cells than human eukaryotic cells, and more and more, we are learning that these microbes that make up ?us? play a fundamental role in regulating brain development and function, and behavior. Microbes modulate host levels of neuroactive molecules, including neurotransmitters and neuropeptides, as well as complex behaviors, such as social, communicative, emotional and anxiety-like behaviors. Alterations in the microbial communities that inhabit us are further implicated in a variety of neurological disorders, including autism, depression and Parkinson's disease. Situated at the interface of neurobiology, immunology and microbiology, we are using integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?
Vuong H. E., Hsiao E. Y., "Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder", Biological Psychiatry, (2016) [link].
Olson C. A., Vuong H. E., Hsiao E. Y., "Equestrian (Microbial Modulators of Host Behavior)", The Microbial Olympics 2016, 1 : 16122- (2016) [link].
Yano J. M., Hsiao E. Y., "A role for the microbiota in neurodevelopmental disorders", In: The Gut-Brain Axis: Dietary, Prebiotic and Probiotic Interventions on the Microbiota, Hyland, N., Stanton, C.(Eds.), 305-318 (2016) .
Malkova N., Hsiao E. Y., "Non-genetic causes of autism spectrum disorders: the role of the immune system", In: Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability, Sala, C., Verpelli, C.(Eds.), 65-76 (2016) .
Malkova N., Wu W., Hsiao E. Y., "Modeling the maternal immune activation risk factor for schizophrenia", Modeling the Psychopathological Dimensions of Schizophrenia and Related Psychoses, Pletnikov, M., Waddington, J.(Eds.), 175-193 (2015) .
Yano J. M., Yu K., Donaldson G., Shastri G., Ma L., Ann P., Nagler C., Ismagilov R. F., Mazmanian S. K., Hsiao E. Y., "Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis", Cell, 161 : 264-276 (2015) .
Hsiao E. Y., "Gastrointestinal issues in autism spectrum disorder", Harv Rev Psychiatry, 22 : 104-111 (2014) .
Hsiao E. Y., "Immune dysregulation in autism spectrum disorder", Int Rev Neurobiol, Konopka G., Harris A., Jenner P.(Eds.), 72 : 269-302 (2013) .
Hsiao E. Y., McBride S. W., Hsien S., Sharon G., Hyde E. R., McCue T., Codelli J. A., Chow J., Reisman S. E., Petrosino J. F., Patterson P. H.*, Mazmanian S. K., "The microbiota modulates behavioral and physiological abnormalities associated with neurodevelopmental disorders", Cell, 155 : 1451-1463 (2013) .
Hsiao E. Y., Patterson P. H., "Placental regulation of maternal-fetal interactions and brain development", Dev Neurobiol, 72 : 1317-1326 (2012) .