office: 1125 Terasaki Life Sciences Bldg
research interests: Mechanics and Physiology of Biological Materials
B.Sc., Physics (honors, With Distinction), Mount Allison University 1998
B.A., Asian Studies, French, & Math (honors), Mount Allison University 1999
M.Sc., Chemistry, Technical University of Denmark 2000
Ph.D., Physics, University of Southern Denmark 2005
My laboratory aims to characterize the physical and mechanical properties of biological matter, infer their molecular origins, and uncover their role in physiological processes. We focus on two broad questions: (1) What are the molecular origins of cell and nuclear physical properties? (2) What are the consequences of cell and nuclear physical properties in physiology and disease? The physical properties of cells and nuclei are central to genome integrity, gene expression, and mechanotransduction; while altered cell mechanotype is the hallmark of a wide variety of diseases from cancer to laminopathies, the origins and consequences of these physical changes are incompletely understood. To achieve this goal, we study the mechanical properties of populations of single cells, using insights from physics and engineering to design new experiments and analyze biological processes ranging from metastasis to mechanotransduction. We also develop novel high throughput technologies to screen cells based on their mechanotype. Our focus on cell mechanotype in physiology and disease is multifaceted and involves the integration of mechanotyping results with data from gene and protein expression, bioinformatics analyses, and functional assays. This new class of experiments will enable us to build a deeper fundamental understanding of the origins of cell mechanical properties and advance mechanotype for clinical applications.
Kim TH, Ly C, Christodoulides A, Nowell CJ, Gunning PW, Sloan EK♯, Rowat AC♯., "Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function", FASEB Journal, (2019) .
Sobreiro MR, Chen JF, Novitskya T, You S, Morley S, Steadman K, Gill NK, Eskaros A, Rotinen M, Chu CY, Chung LWK, Tanaka H, Yang W, Knudsen BS, Tseng HR, Rowat AC, Posadas EM, Zijlstra A, Di Vizio D, Freeman MR, "Emerin deregulation links nuclear shape instability to metastatic potential", Cancer Research, 78 (21): 6086-6097 (2018) [link].
Nyberg KD, Bruce SL, Nguyen AV, Chan CK, Gill NK, Kim TH, Sloan EK, Rowat AC, "Predicting cancer cell invasion by single-cell physical phenotyping", Integrative Biology, 10 : 218-231 (2018) .
Kim TH, Rowat AC*, Sloan E*, "Neural regulation of cancer: from mechanobiology to inflammation", Clinical and Translational Immunology, 5 : e78- (2016) .
Lautscham, L.A., Kaemmerer, C., Lange, J., Kolb, T., Mark, C., Schilling, A., Strissel, P., Strick, R., Gluth, C., Rowat, A.C., Metzner, C., Fabry, B., "Migration in confined 3D environments is determined by a combination of adhesiveness, nuclear volume, contractility, and cell stiffness", Biophys. J, 109 : 1-14 (2015) .
Zhou L, Nyberg K, Rowat AC, "Understanding Fick's law and diffusion theory through food & cooking", Adv. Physiol. Edu, 39 : 192-197 (2015) .
Soh, M., Roth-Johnson, E.A., Levis, M., Rowat, A.C., "Interactive taste tests enhance student learning", Adv. Physiol. Edu, 45 : 44-48 (2015) .
Clarke, C.F., Rowat, A.C., Gober, J.W., "Is CoQ a membrane stabilizer?", Nat. Chem. Biol, 10 : 242-243 (2014) .
Rowat, A.C., "The Molecules We Eat: Food as a Medium to Communicate Science", Flavour, 2 : 10- (2013) .
Rowat, A.C., Jaalouk, D.E., Zwerger, M., Ung, L., Eydelnant, I., Olins, D.E., Olins, A., Herrmann, H., Weitz, D.A., and Lammerding, J., "Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions", J. Biol. Chem, 288 : 8610-8618 (2013) .