Faculty Spotlight


Xia Yang

Xia Yang

Common metabolic disorders such as coronary artery disease, diabetes, and obesity represent top health concerns worldwide. These diseases are not only highly interconnected but also linked to various other diseases such as cancers and neurodegenerative diseases. We hypothesize that the complex interactions between genetic and environmental risk factors perturb specific gene networks which in turn induce variations in disease susceptibility and therapeutic response. Research in our lab employs integrative genomics and systems biology approaches that leverage various large-scale molecular datasets, such as genome-wide genetic, transcriptional, epigenomic, and relevant phenotypic data from human and rodent populations to identify causal molecular alterations and the subsequently perturbed molecular networks that contribute to the development of obesity, diabetes, and cardiovascular diseases. The candidate causal components and networks identified will serve as the basis for therapeutic target and biomarker discovery as well as for patient stratification with respect to clinical outcome or pharmacological response.





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