Home
What is DMD
About UCLA DMD
Center Scientists
Seminars
Contact Us
News
support UCLA DMD Research Center
links for parents
jobs

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publications of Center Scientists

Villalta, S.A., Rinaldi, C., Deng, B., Liu, G., Fedor, B. and J. G. Tidball. 2011. Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype. Human Molecular Genetics. In press.

Wehling-Henricks, M., M. C. Jordan, T. Gotoh, W. W. Grody, K. P. Roos and J. G. Tidball. 2010. Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy. PLoS One e10763. doi:10.1371/journal.pone.0010763.

Tidball, J.G. and S.A. Villalta. 2010. Interactions between muscle and the immune system regulate muscle growth and regeneration. Amer. J. Physiol. 298:R1173-1187.

Dorshkind K. 2010. Not a split decision for human hematopoiesis. Nature Immunol. 11:569-70.

Wehling-Henricks, M., M. Oltmann, C. Rinaldi, K. H. Myung, and J. G. Tidball. 2009. Loss of positive allosteric interactions between neuronal nitric oxide synthase and phosphofructokinase contributes to defects in glycolysis and increased fatigability in muscular dystrophy. Human Molec. Genetics 18:3439-3451.

Tidball, J.G. and S.A. Villalta. 2009. Nitric oxide may prompt calcium leakage in dystrophic muscle. Nature Medicine 15:243-244.

Deng, B., D. Glanzman and J.G. Tidball. 2009. Nitric oxide generated by muscle corrects defects in hippocampal neurogenesis and neural differentiation caused by muscular dystrophy. J. Physiol. (Lond.) 587: 1769-1778.

Tidball, J.G. and M. Wehling-Henricks. 2009. Inflammatory mechanisms in genetic neuromuscular disorders. In: Inflammatory and autoimmune disorders of the nervous system in children. R. C. Dale and A. Vincent, eds. Cambridge Univ. Press. pages 455-479.

Villalta, S.A., H.X. Nguyen, B. Deng, T. Gotoh and J.G. Tidball. 2009. Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy. Human Molec. Genetics 18:482-496.

Dorshkind, K. and S. Swain. 2009. Age-associated declines in immune system development and function: causes, consequences, and reversal. Current Opinion in Immunology. 21(4):404-407.

Dorshkind, K., Montecino-Rodriguez, E. and Signer, R.A. 2009. The ageing immune system: is it ever too old to become young again? Nature Rev. Immunol. 9(1):57-62.

Perez, A.L., E. Bachrach, B.M. Illigens, S.J. Jun, E. Bagden, L. Steffen, A. Flint, F.X. McGowan, P. Del Nido, E. Montecino-Rodriguez, J.G. Tidball and L.M. Kunkel LM. 2009. CXCR4 enhances engraftment of muscle progenitor cells. Muscle Nerve 40(4):562-72.

Dorshkind, K. and S. Swain. 2009. Age-associated declines in immune system development and function: causes, consequences, and reversal. Curr. Opin. Immunol.21(4):404-7.

Signer, R.A., Montecino-Rodriguez, E., Witte, O.N. and Dorshkind, K. 2008. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 22(22):3115-20.

Wehling-Henricks, M., Sokolow, S., Lee, J.J., Myung, K.H., Villalta, S.A., and J.G. Tidball. 2008. Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy. Human Molec. Genetics 17:2280-2292.

Hao, M., K. Akrami, K. Wei, C. De Diego, N. Che, J.H. Ku, J.G. Tidball, M.C. Graves, P.B. Shieh and F. Chen. 2008. Muscleblind-like 2 (Mbnl2) -deficient mice as a model for myotonic dystrophy. Dev. Dyn. 237:403-10.

Tidball, J.G. 2008. Inflammation in skeletal muscle regeneration. In: Skeletal muscle repair and regeneration. S. Schiafano and T. Partridge, eds. Springer. Pp. 243-68.

Acharyya, S., S.A. Villalta, N. Bakkar, T. Bupha-Intr, P.M.L. Janssen, M. Carathers, M. Karin, Z. Li, A. Beg, S. Ghosh, Z. Sahenk, M. Weinstein, K.L. Gardner, J.A. Rafael-Fortney, J.G. Tidball, A.S. Baldwin and D.C. Guttridge. 2007. IKK/NF-kB signaling interplay in macrophages and myofibers promotes muscle wasting in Duchenne muscular dystrophy. J. Clin. Invest. 117:889-901.

Tidball, J.G. and M. Wehling-Henricks. 2007. The role of free radicals in the pathophysiology of muscular dystrophy. J. Appl. Physiol. 102:1677-1686.

Tidball, J.G. and M. Wehling-Henricks. 2007. Macrophages promote muscle membrane repair and muscle fiber growth and regeneration during modified muscle loading in mice in vivo. J. Physiol. (Lond.). 578.1: 327-336.

Dorshkind, K. and Witte, O.N. 2007. Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL. Genes Dev. 21(18):2249-52.

Monroe, J.G. and Dorshkind, K. 2007. Fate decisions regulating bone marrow and peripheral B lymphocyte development. Adv. Immunol. 95:1-50.

Yang, G.X,, Lian, Z.X., Chuang, Y.H., Shu, S.A., Moritoki, Y., Lan, R., Wakabayashi, K., Ansari, A.A., Dorshkind, K., Ikehara, S., Gershwin, M.E. 2007. Generation of functionally distinct B lymphocytes from common myeloid progenitors. Clin. Exp. Immunol. 150(2):349-57.

Hardy, R.R., Kincade, P.W. and Dorshkind, K. 2007. The protean nature of cells in the B lymphocyte lineage. Immunity 26(6):703-14.

Montecino-Rodriguez, E. and Dorshkind, K. 2006. Stromal cell-dependent growth of B-1 B cell progenitors in the absence of direct contact. Nature Protoc. 1(3):1140-4.

Dorshkind, K. and Montecino-Rodriguez, E. 2007. Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential. Nature Rev. Immunol. 7(3):213-9.

Montecino-Rodriguez, E., and Dorshkind, K. 2006. New perspectives in B-1 B cell development and function. Trends Immunol. 27(9):428-33.

Montecino-Rodriguez E, Dorshkind K. 2006. Evolving patterns of lymphopoiesis from embryogenesis through senescence. Immunity 24(6):659-62.

Smale, S.T. and Dorshkind, K. 2006. Hematopoiesis flies high with Ikaros. Nature Immunol. 7(4):367-9.

Montecino-Rodriguez, E., Leathers, H. and Dorshkind, K. 2006. Identification of a B-1 B cell-specified progenitor. Nature Immunol. 7(3):293-301.

Tidball, J.G. 2006. Heat shock protein function in skeletal muscle injury and disease. In: Heat Shock Proteins in Biology and Medicine. J. Radons and G. Multhoff, eds. Research Signpost Press. p. 353-367.

Tidball, J.G. and M. Wehling-Henricks. 2005. Damage and inflammation in muscular dystrophy: potential implications and relationships to autoimmune myositis. Curr. Opinion Rheum. 17: 707-713.

Wehling-Henricks, M., M.C. Jordan, K.P. Roos, B. Deng and J. G. Tidball. 2005. Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium. Human Molec Genetics 14: 1921-1933.

Nguyen H.X., A.J. Lusis and J.G. Tidball. 2005. Null mutation of myeloperoxidase in mice prevents mechanical activation of neutrophil lysis of muscle cell membranes in vitro and in vivo. J. Physiol. (Lond.) 565.2: 403-13.

Tidball, J.G. 2005. Inflammatory processes in muscle injury and repair. Amer. J. Physiol. 288: R345-353.

Tidball, J.G. 2005. Mechanical signal transduction in skeletal muscle growth and adaptation. J. Appl. Physiol. 98:1900-1908.

Dogusan, Z., Montecino-Rodriguez, E. and Dorshkind, K. 2004. Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells. J. Immunol. 2004. 172(8):4717-23.

Dorshkind, K. and Witte, O. 2004. Got MLL? Definitive hematopoiesis requires MLL gene expression. Mol. Cell. 13(6):765-6.

Linton, P.J. and Dorshkind, K. 2004. Age-related changes in lymphocyte development and function. Nature Immunol. 5(2):133-9.

Tidball, J.G. and M. Wehling-Henricks. 2004. Evolving therapeutic strategies for Duchenne muscular dystrophy: targeting downstream events. Pediatric Res. 56: 831-841.

Tidball, J.G. and M. Wehling-Henricks. 2004. Expression of a NOS transgene in dystrophin-deficient muscle reduces muscle membrane damage without increasing the expression of membrane-associated cytoskeletal proteins. Molecular Genetics and Metabolism 82(4):312-320.

Shiao, T., A. Fond, B. Deng, M. Wehling-Henricks, M.E. Adams, S.C. Froehner, and J. G. Tidball. 2004. Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking alpha- and beta-1-syntrophins. Human Molec. Genetics 13: 1873-1884.

Wehling-Henricks, M., J.J. Lee and J.G. Tidball. 2004. Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient muscle. Neuromus. Disorders 14:483-90.

Nguyen, H.X. and J.G. Tidball. 2003. Null mutation of gp91phox reduces muscle membrane lysis during muscle inflammation. J. Physiol. (Lond.) 553: 833-841.

Tidball, J.G. and M.J. Spencer. 2003. Skipping along to new gene therapeutics for muscular dystrophy. Nature Medicine 9: 997-998.

Nguyen, H.X. and J.G. Tidball. 2003. Expression of a muscle-specific, nitric oxide synthase transgene prevents muscle membrane injury and reduces muscle inflammation during modified muscle use. J. Physiol. (Lond). 550: 347-356.

Nguyen, H.X. and J.G. Tidball. 2003. Interactions between neutrophils and macrophages promote macrophage killing of muscle cells in vitro. J. Physiol. (Lond). 547: 125-132.

Montecino-Rodriguez, E. and Dorshkind, K. 2003. To T or not to T: reassessing the common lymphoid progenitor. Nature Immunol. 4(2):100-1.

Dorshkind, K. 2002. Stem cells and lineage plasticity: the challenge to existing paradigms. Immunol. Rev. 187:5-8.

Paquette, R. and Dorshkind, K. 2002. Optimizing hematopoietic recovery following bone marrow transplantation. J. Clin Invest. 109:1527-8.

Dorshkind, K. 2002. Multilineage development from adult bone marrow cells. Nature Immunol. 3(4):311-3.

Tidball, J.G. and M.J.Spencer. 2002. Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin expression during mouse muscle disuse. J. Physiol. (Lond). 545: 819-828.

Tidball, J.G. and M.J.Spencer. 2002. Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin expression during mouse muscle disuse. J. Physiol. (Lond). 545: 819-828.

Tidball, J.G. 2002. Interactions between muscle and the immune system during modified musculoskeletal loading. Clinical Orthop. Rel. Res. 400S: 100-109.

Wehling, M., M.J. Spencer, and J.G. Tidball. 2001. A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice. J. Cell Biol. 155: 123-131.

Spencer, M.J. and J.G. Tidball. 2001. Do immune cells promote the pathology of dystrophin-deficient myopathies? Neuromuscular Disorders 11: 556-564.

Spencer, M.J., E. Montecino-Rodriguez, K. Dorshkind and J.G. Tidball. 2001. Helper (CD4+) and cytotoxic (CD8+) T cells promote the pathology of dystrophin-deficient muscle. Clinical Immunol. 98: 235-243.

Montecino-Rodriguez, E., Leathers, H., Dorshkind K. 2001. Bipotential B-macrophage progenitors are present in adult bone marrow. Nature Immunol. 2(1):83-8.

Dorshkind K. 2000. Understanding how pre-B cells come of age.
Nature Immunol. 1(5):369-70.

Zhu, X., M. Hadhazy, M. Wehling, J.G. Tidball and E.M McNally. 2000. Dominant negative myostatin produces hypertrophy without hyperplasia in muscle. FEBS Lttrs. 474: 71-75.

Koh, T.J. and J.G. Tidball. 2000. Nitric oxide inhibits calpain-mediated proteolysis of talin in skeletal muscle cells. Amer. J. Physiol. (Cell Physiol.) 279: C806-C812.

Cai, B., M. J. Spencer, G. Nakamura, and J.G. Tidball. 2000. Eosinophilia of dystrophin-deficient muscle is promoted by perforin-mediated cytotoxicity by T-cell effectors. Amer. J. Pathol. 156: 1789-1796.

Wehling, M., B. Cai and J.G. Tidball. 2000. Modulation of myostatin expression during modified muscle use. FASEB J. 14: 103-110.

Tidball, J.G. and M. Spencer. 2000. Calpains and muscular dystrophies. Int. J. Biochem. Cell Biol. 32:1-5.

Frenette, J., B. Cai and J.G. Tidball. 2000. Complement activation promotes muscle inflammation during modified muscle use. Amer. J. Pathol. 156: 2103 - 2110.

Wehling, M, J.T. Stull, T.J. McCabe and J.G. Tidball. 1998. Sparing of mdx extraocular muscles from dystrophic pathology is not attributable to normalized concentration or distribution of neuronal nitric oxide synthase. Neuromuscular Disorders 8: 22-29.

Spencer, M.J., C. Walsh, K.A. Dorshkind, E. Montecino-Rodriguez and J.G. Tidball. 1997. Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity. J. Clin. Invest. 99: 2745-51.

Chang, W-J. S.T. Iannaccone, K.S. Lau, B.S.S. Masters, T.J. McCabe, K. McMillan, R.C. Padre, M.J. Spencer, J.G. Tidball and J.T. Stull. 1996. Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy. Proc. Natl. Acad. Sci., USA 93: 9142-9147.

Spencer, M.H., D.E. Croall and J.G. Tidball. 1995. Calpains are activated in necrotic fibers from mdx dystrophic mice. J. Biol. Chem. 270:10909-10914.

Tidball, J.G., D.E. Albrecht, B.E. Lokensgard and M.J. Spencer. 1995. Apoptosis precedes necrosis of dystrophin-deficient muscle. J. Cell Sci. 108:2197-2204.